Scientist I

Shift: 1st Work Schedule: Mon-Fri 8AM-4PM

We are looking for a highly motivated scientist to join our structural biology and biophysics group at client in Cambridge MA. As a key member of our dynamic team, you will be responsible for determining critical structural biology data through both cryo-electron microscopy and x-ray crystallography; actively pursuing solutions for unmet medical needs in diverse therapeutic areas and collaborating with multidisciplinary teams within client in Cambridge, US, Frankfurt, Germany and Paris, France. The successful candidate will excel in a fast-paced, highly diverse discovery environment, will have a strong focus on scientific rigor, have proven success in organized and independent work, and an exceptional attention to detail. Applicants who are passionate about structural biology are encouraged to apply.
Candidate profile:
• X-ray and CryoEM expert scientist that can independently design and carry out x-ray, EM experiments and interpret results (sample preparation, data collection, data processing and solving structures). Analyze interactions and propose structure-based improvements for small-molecule drug discovery. Enable building state-of-the art technologies in related areas to enhance research activities.
• Expertise with all related softwares (CryoSparc, SerialEM, Relion, cisTEM, Chimera, Eman2, Coot, phenix, ccp4 suite etc.).
• Provide expertise to project teams pursuing different drug modalities at Client.
• Manage and deliver on projects in a timely fashion.
• Experience in biophysical characterization (SPR, DSF, MST etc.) is a plus.
• Have excellent communication skills. Should be able to clearly articulate data, project strategies both internally and externally.
Responsibilities
/ Duties
• Determine structural biology data using cryo-electron microscopy (Cryo-EM) and X-ray crystallography.
• Design and conduct experiments independently for structure determination, including:
o Sample preparation
o Data collection
o Data processing
o Structure solving
• Analyze molecular interactions and propose structure-based optimizations to support small-molecule drug discovery.
• Provide scientific expertise to project teams working on different drug modalities.

Qualifications:
PhD with 1+yrs of postdoctoral and/or industry experience in Structural Biology, Biophysics, Protein Biochemistry or related discipline. Strong experience in cryo-EM and x-ray crystallography is required. The ideal candidate should be detail-oriented, organized and demonstrate good lab practices. Must be a collaborative team player with strong communication skills.