Senior Research Technician

Overview

Overview
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

The Fischer Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology Lab that combines a broad range of laboratory techniques to study the pathways and protein complexes involved in the regulation of protein homeostasis often associated with human diseases, including cancer. Using our knowledge of the cellular degradation machinery, we use structure and computational guided approaches to develop and test new molecules that hijack the ubiquitin proteasome system for targeted protein degradation. Combining fundamental mechanistic insights with translational chemical biology research, we are pioneering new therapeutic avenues.

The Fischer lab ( seeks a highly motivated individual to join the team as a SENIOR RESEARCH TECHNICIAN . This individual will be an important member of our research team and will be centrally involved in assisting various research projects of the Fischer Lab. In addition to the bench-based research, responsibilities will also include some aspects of laboratory management and organization. Training is available in all aspects of experimental research.

Responsibilities

• Responsible for the operation and maintenance of Biacore 8K SPR instrument, including compound screening and troubleshooting
• Prepares lab reagents and media
• Performs protein expression and purification procedures
• Conduct standardized biological or biochemical assays and laboratory analyses, eg. TR-FRET, FP, pull downs, cell-based assays, western blot, flow cytometry
• Analyzes experimental data and interpret results to write reports, presentations, grant and publication preparation
• Uses computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties.
• Maintains detailed notebook of all work-related activities
• Operation and maintenance of standard lab equipment
• Maintains and orders laboratory supplies
• Communicates with purchasing and may be responsible for negotiating with vendors

Qualifications

• Bachelor's Degree required with a major in biology, chemistry or “pre-med” preferred.
• Research experience (>2-3 yr) in molecular biology or biochemistry preferred.
• Prior experience with SPR preferred.
• Ability to analyze information and use logic to address work-related issues and problems.
• Must have close attention to detail and consistent work habits.
• Ability to work within a team environment.
• A minimum time commitment of 2 years is preferred.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.