Senior Scientist-Uppaluri Lab

Overview

The Senior Scientist works on problems of diverse scope in which analysis of data requires evaluation of identifiable factors. Exercises judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions. Has a wide latitude for decision-making working in conjunction with the PI. Works closely with senior managers and directors on unit/lab issues. Manages the work efforts of at least one individual contributor, mentor's other lab members, and completes performance appraisals. Contributes broad knowledge of the field, strong leadership skills, technical proficiency, and scientific creativity. Works both collaboratively and independently.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Research in the Uppaluri Lab

Our efforts are focused on understanding the basic biology of HNSCCs and translating these findings to benefit patients. These are divided into below approaches.
1. HNSCC modeling
a. Developed syngeneic HNSCC cell lines called the mouse oral carcinoma (MOC) model.
b. Generated a bank of patient derived xenografts oral cavity SCCAs
c. Current efforts include expanding PDX modeling and generating antiPD1 resistant, syngeneic models

2. Neoantigen biology and immunotherapy response

3. Immunotherapy resistance including with CRISPR screening

4. Mechanisms of response and resistance to MEK inhibition in HNSCCs

5. Clinical trials- novel neoadjuvant clinical trial approaches. PI or co-investigator in below trials

The goal of our laboratory efforts is to couple understanding of the basic biology of head and neck squamous cell carcinomas (HNSCCs) with translational findings to ultimately transform how we take care of affected patients.

We study the basic immunobiology of the anti-tumor immune response, pathways impacted by targeted therapeutics and correlative clinical responses in HNSCC patients.

We utilize (1) preclinical HNSCC model systems, (2) patient derived samples and xenografts and (3) novel clinical trial designs that together advance our understanding of HNSCCs.

Primary Duties and Responsibilities

• Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought. Works on problems of diverse scope in which analysis of data requires evaluation of identifiable factors.
• Exercises judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions.
• Works closely with senior managers and directors on unit/lab issues. Wide latitude for decision-making working in conjunction with the PI.

Knowledge, Skills and Abilities

• Broad knowledge of the field with strong leadership skills. Resolves issues and contributes to unit/lab development.

Minimum Job Qualifications

• Advanced degree preferred.
• 6+ years experience post education; One year management responsibility.

License/Certification/Registration Required: None

Supervisory Responsibilities:

• Manages the work efforts of at least one individual contributors and mentors.
• Completes performance appraisals.

Patient Contact: None

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionate professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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Pay Transparency Statement

The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications.

For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).

$95,000.00 - $125,100.00