Senior Clinical Trial Manager (Hybrid)

Job Title: Senior Clinical Trial Manager

Job Description

We are seeking a Senior Clinical Trial Manager to oversee and manage all clinical site interactions, including IRB/EC applications, contract negotiations, enrollment tracking, and issue resolution. This role involves owning and managing trial start-up, conduct, and close-out activities according to industry and corporate standards, contributing to key clinical documents, and establishing professional rapport with investigational site personnel.

Responsibilities

• Manage all clinical site interactions including IRB/EC applications, contract negotiations, enrollment tracking, clinical trial material and clinical supply requests, and issue resolution.

• Own and manage all trial start-up, conduct, and close-out activities according to industry and corporate standards.

• Contribute to preparation of key clinical documents such as protocols, informed consent, amendments, CRFs, training materials, project plans, monitoring plans, data plans, SAPs, and reports.

• Establish professional rapport and frequent communication with investigational site personnel.

• Track internal metrics, timelines, and budgets.

• Communicate trial status and prepare/present updates to management.

• Oversee monitoring activities to ensure compliance with GCP, ICH, FDA regulations, SOPs, and protocols.

• Interact with data management teams to plan and execute analyses.

• Support applications and technical files as needed.

• Collaborate with DSMB, CEC, and other committees.

• Assist with investigators' meetings and manage vendors.

• Travel up to 25% of the time.

• Perform other duties as assigned.

Essential Skills

• 8-10 years of clinical research experience with at least 3-5 years of trial management experience.

• Medical device experience required.

• Previous monitoring experience highly preferred.

• Expertise in IRB/EC submissions and approvals.

• Track record leading complex global clinical trials.

Additional Skills & Qualifications

• Cardiovascular experience preferred.

Work Environment

The position is based in Andover, MA, and will initially require full on-site work for the first three months. Following this period, the role will transition to a hybrid schedule, working four days a week on-site. The clinical operations team is a small, collaborative group of 13 people, embodying a 'lean and mean' ethos.

Job Type & Location

This is a Contract to Hire position based out of Andover, MA.

Pay and Benefits

The pay range for this position is $70.00 - $80.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: - Medical, dental & vision - Critical Illness, Accident, and Hospital - 401(k) Retirement Plan - Pre-tax and Roth post-tax contributions available - Life Insurance (Voluntary Life & AD&D for the employee and dependents) - Short and long-term disability - Health Spending Account (HSA) - Transportation benefits - Employee Assistance Program - Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a hybrid position in Andover,MA.

Application Deadline

This position is anticipated to close on Feb 20, 2026.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email [email protected] (%[email protected]) for other accommodation options.