Senior Director, SOX Compliance

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Title: Senior Director, SOX Compliance

Department: Accounting

Location: Waltham, MA (Hybrid 3 days per week)

About Madrigal

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Position Overview

Madrigal Pharmaceuticals is seeking an accomplished Senior Director, SOX Compliance to lead the company’s enterprise-wide Sarbanes-Oxley (SOX) program. This role will be instrumental in making updates to Madrigal’s current control environment, focusing on ensuring a continued sustainable control framework that supports Madrigal’s global commercial expansion and public company responsibilities. The Senior Director will collaborate across functions to strengthen internal controls, mitigate risk, and ensure compliance with SOX 404 requirements while fostering a culture of operational excellence and accountability.

Key Responsibilities

SOX Program Leadership

• Maintain and enhance Madrigal’s SOX compliance program, including scoping, risk assessment, control design, documentation, testing, remediation, and ongoing monitoring.
• Partner with Finance, IT, Legal, HR, and business operations to ensure controls are properly designed and operating effectively across all key processes and systems.
• Lead the annual SOX risk assessment and control initiatives to ensure compliance efforts are efficient and aligned with business priorities.
• Lead annual internal and external process walkthroughs.
• Manage relationships with external auditors and consultants to ensure timely coordination of SOX testing and reporting.
• Drive continuous improvement of SOX-related processes, automation opportunities, and control environment maturity.
• Lead RFP and implementation process for SOX software.
  
  

Cross-Functional Collaboration & Governance

• Serve as the primary point of contact for SOX matters across the organization, including executive management and the Audit Committee.
• Communicate control deficiencies, testing results, and remediation progress in a clear, actionable manner to senior leadership.
• Partner closely with Finance and IT leadership to ensure alignment between control requirements, system implementations, and process changes.
• Provide strategic insight and guidance on internal control implications of new business initiatives, system implementations, and policy changes.
  
  

Risk Management & Continuous Improvement

• Monitor evolving regulatory expectations, PCAOB standards, and best practices in internal control frameworks (e.g., COSO 2013) to ensure Madrigal remains compliant and forward-looking.
• Evaluate emerging risks and operational changes that could impact the control environment, proposing proactive mitigations where appropriate.
• Promote a strong control culture throughout the organization by training and mentoring control owners and stakeholders.
  
  

Qualifications And Skills Required

• Bachelor’s degree in Accounting, Finance, or related field; CPA or CIA required.
• 15+ years of progressive experience Finance with 5+ years in SOX compliance, internal controls, and risk management — ideally including both public accounting and corporate experience in the biotech or pharmaceutical industry.
• Proven success building or transforming a SOX function within a complex, global organization.
• Deep knowledge of SOX 404 compliance, COSO frameworks, internal controls, and PCAOB standards.
• Strong understanding of IT general controls (ITGCs), automated controls, and system implementation risk.
• Exceptional communication and leadership skills with the ability to influence and align stakeholders across all levels of the organization.
• Demonstrated ability to build and mentor a high-performing team and effectively manage external partners.
• Willingness to travel up to ~10% (domestic and international).
  
  

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $245,000 - $299,000 per year.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected].

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected] .