Global Head of Research and Biomarkers- Vaccines
Sanofi (US)
Waltham, MA
Job Title: Global Head of Research and Biomarkers- Vaccines Location: Waltham, MA About the Job Join the team protecting half a billion lives every year with next-gen science, mRNA innovation, and AI-driven breakthroughs. In Vaccines, you’ll help advance prevention on a global scale - and shape the future of immunization. Sanofi is a global biopharmaceutical company focusing on human health transforming scientific innovation in healthcare solutions. At Sanofi, we innovate in immunology, rare diseases & prevention. Sanofi Pasteur has been a leader in the vaccine industry for over 100 years. We are building a world in which no one suffers or dies from a vaccine preventable disease. We produce more than 1 billion doses of high-quality vaccines each year and save over 3 million lives worldwide. Sanofi Pasteur is embracing the digital revolution. Today we incorporate big data, machine learning and advanced analytics into R&D, evidence generation, commercial operation and manufacturing. mRNA technology stands at the forefront of these scientific breakthroughs. In an ever-evolving healthcare landscape, we recognize mRNA's transformative potential to revolutionize how we prevent and treat diseases, making innovative solutions accessible to more people, faster than ever before. That's why we've established our mRNA Center of Excellence. With an annual investment of €200m and a dedicated team of 500+ experts, we built an integrated end-to-end mRNA platform that brings together R&D, digital capabilities, and CMC expertise under one roof. Bring your ambition and optimism and join us on our journey to discover and deliver transformative medicine to patients through the advancement of our cutting-edge mRNA technology! In this role, the CTO, Global Head of Research & Biomarkers will be overseeing the overall end to end COE Research group covering pDNA, mRNA & Delivery (including Lipids discovery, associated synthesis) research teams and capabilities supporting Sanofi ambition in the field of therapeutic and prophylactic approaches serving unmet medical needs. Additionally, the CTO, Global Head of Research & Biomarkers will oversee a best-in-class mRNA Biomarker platform team based in France and Orlando, with the aim to:
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system - and innovative pipeline - enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives. Main Responsibilities: Lead, engage, drive and develop a team whose mission is to conduct research on mRNA, LNP and formulation (Delivery) design for various applications and specific routes of administration, including:
#LI-SP #LI-Hybrid
#vhd #mRNA All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
- maximize efficacy and safety of LNP-mRNA through deep molecular and cellular immune profiling,
- deciphering the impact of the LNPs components on immune innate response as well as overall humoral and cellular immunity,
- as such, we will gain confidence in mRNA-based technology performance prediction.
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system - and innovative pipeline - enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives. Main Responsibilities: Lead, engage, drive and develop a team whose mission is to conduct research on mRNA, LNP and formulation (Delivery) design for various applications and specific routes of administration, including:
- The support for the targeted disease scientific strategic approach definition,
- The discovery and evaluation of new delivery system (non LNP delivery) and its associate requirements (Pharmaceutical form, route of admin ...),
- The identification and synthesis of novel lipids or alternative in link with the mechanism of action foreseen,
- The identification and development of novel mRNA stabilization approaches,
- The research of novel elicitors of mRNA intracellular mRNA translation,
- The development of mRNA formulation,
- High throughput screening of excipients,
- Thermostable fully liquid formulation,
- Lyo/spray dried formulation,
- As such the team screen for new technologies and establish those technologies to improve mRNA generation capabilities and identify novel approaches that leverage the mRNA platform in the development of new or better prophylactic and therapeutic targets.
- In order to accelerate mRNA & LNO research, the Global Head of R&B will ensure that all the digital briks (Automation, IA, ML) required for such technology are leveraged at scale.
- Define and execute the biomarker strategy supporting the optimization, the development, the manufacturing, and the registration of mRNA + LNP for prophylactic and Therapeutic vaccines / application,
- Discover, develop and validate in vitro, in vivo preclinical and clinical biomarker assays,
- Support the overall CMC DS & DP group by analyzing samples via established biomarker platform,
- Ensure smooth transfer of analytical methods to analytical group
- Apply molecular biology and cell biology to advance and optimize RNA-based vaccine technology,
- Perform molecular techniques that include (but are not limited to) recombinant DNA techniques, sequence analysis, DNA/RNA isolation etc.
- Support strategic writing of the CMC section of the regulatory dossier
- Is responsible for the selection, attraction, and retention of talents within mRNA CoE
- Provide best environment and support to project teams and scientists
- Act as the spokesperson/host for Vx R&D at site events, visitor welcomes and site visits.
- Act as a liaison to transfer information between Vx R&D and other functions. Vx R&D representative at the National Hub Leadership Team.
- Be the voice of the site for Vx R&D externally, interactions with local communities as appropriate and in collaboration with External Engagement teams
- Contribute to Vx R&D communication strategy at local level
- Lead initiatives to promote culture change, work performance, innovation & well- being
- PhD in Biotechnology or related field, 15+ years of relevant work experience (Discovery, Research and CMC...) with biopharmaceutical / biotech industry in Biologics, Gene Therapy, Cell Therapy...
- Strong expertise in molecular biology technics including analytical technics,
- Experience with lipid chemistry, lipid modifications, lipid synthesis, and standard analytical techniques for macromolecules,
- Expertise in encapsulation technics, advanced formulation for Oligo/Lipids based products
- Expertise in cell biology (e.g. cell culture, transfections, ELISA, and flow cytometry including cell sorting)
- Experience in nanoparticle characterization techniques (DLS, zeta potential, chromatography......)
- Experience in immunological and biochemical assay development experience in translational medicine is a real asset
- Desire to initiate and apply innovative approaches to early drug development and predictive modeling
- Proven track of record of managing direct reports and leading teams
- Experience in leading a team (≥ 50 people) of senior scientists, directors and & AVP levels
- Strong team building and leadership skills
- Demonstrate Take The Lead behaviors
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
#LI-SP #LI-Hybrid
#vhd #mRNA All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
Posted 2026-01-12
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