Senior Computational Biologist

Role Summary

Pfizer’s Machine Learning and Computational Sciences group is seeking a highly skilled computational biologist with experience in bioinformatics workflow and data management method development.

The role involves analyzing high-throughput sequencing and multi-omics data to support the development of analytical assays and the characterization of oligonucleotide-based therapeutics. The successful candidate will be responsible for developing statistically rigorous analytical methods and building and managing both internal and publicly available databases. This will be achieved through close collaboration with a diverse community of experimental scientists across various research sites.

This position requires a strong educational and research background in both computational biology and biostatistics in addition to a thorough understanding of molecular biology. The ideal candidate will demonstrate enthusiasm for working collaboratively, communicating effectively, and engaging with both computational and experimental scientists to drive innovation and analytical excellence.

Role Responsibilities

• Develop computational methods and workflows to support Pfizer’s portfolio projects focused on nucleic acid products and medicines.
• Streamline and automate complex analytical tasks for short-read and long-read sequencing data to improve efficiency and maintain reproducibility.
• Provide support for data analysis, visualization, interpretation of results, and experimental design feedback across multiple projects.
• Conduct detailed bioinformatics and statistical analyses and maintain documentations within a regulated system.
• Work closely with Research & Development scientists to generate new scientific insights.
• Manage and maintain computational infrastructure and database systems.

Basic Qualifications

• Ph.D. degree in computational biology, biostatistics, computer science, or a related technical field with 0-5 years of industrial experience in the analysis of high-throughput sequencing and other omics datasets.
• Demonstrated high proficiency in programming, with strong skills in Python and workflow languages to efficiently execute and automate workflows and data management tasks.
• Experience in computational tool and package development including version control, unit testing, deployment, and documentation.
• A strong interest in continuously learning and engaging with emerging biological initiatives.
• Attention to detail, documentation skills, ability to multitask, and effective interpersonal and presentation skills.

Preferred Qualifications

• Extensive experience in developing high-throughput sequencing pipelines using the Nextflow workflow development language on a cloud-based platform.
• An in-depth understanding of the statistical methods commonly used in omics analyses.
• Familiarity with cGMP regulatory requirements for data and infrastructure security controls.
• Experience analyzing nucleic acid molecules, large molecules, and vaccines.
• A strong record of well-cited journal publications and presentations.

Additional Information:

• Work Location: Hybrid (live within a commutable distance to a Pfizer site and requirement to work on-site on average 2.5 days/week)
• Last Day to Apply: January 23, 2026

The annual base salary for this position ranges from $106,000.00 to $171,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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Research and Development