Senior Associate Scientist
Location: Cambridge, Massachusetts
Type: Contract
Compensation: $45 - $55 hourly
Contractor Work Model: 4 days onsite, 1 day remote
Hours: 8 AM- 5 PM M-F
Responsibilities:
Responsible for the development of robust, efficient, scalable and transferable lentiviral vector (LVV) manufacturing for early and late-stage cell therapy programs, for both ex-vivo and in-vivo delivery approaches. This role will have the opportunity to directly support current pipeline programs in process development and CMC activities, as well as drive ground breaking technology development of next generation vector processes.
- Complete routine PD-grade viral vector production operations at both bench scale and pilot scale, including but not limited to media preparation, culture initiation, seed train maintenance and bioreactor operations, to support process development studies and material generation for pre-clinical programs.
- Perform viral vector production experiments to assess the impact of process changes and new technologies to drive critical innovation projects for next generation LVV production processes.
- Develop experimental plans, interpret scientific results, and provide statistical analysis where appropriate.
- Perform general laboratory tasks, including maintenance of equipment and inventory.
- Support technology transfer activities to manufacturing partners as an upstream SME.
- Generate, manage, evaluate, and maintain critical data in an organized way, including lab notebook maintenance with good documentation practices.
- BS/MS in Bioengineering, Chemical engineering, Biology, Cell Biology or related biological sciences
- 2+ years (MS), or 4+ years (BS) of proven experience in biotechnology or pharmaceutical industry.
- Understanding of cell biology and hands-on experience with mammalian cell culture is required.
- Experience with vector process development and manufacturing is preferred.
- Experience with bioreactors, control software, and process analytical technology is strongly preferred.
- General knowledge of process development and pharmaceutical manufacturing is helpful.
- Experience with scale-up and pilot plant operations is a plus.
#LI-
#DI- Ref: #558-Scientific
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