M365/Azure Principal Systems Engineer - Remote

Prime Therapeutics
Boston, MA

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At Prime Therapeutics (Prime), we are a different kind of PBM, with a purpose beyond profits and a unique ability to connect care for those we serve. Looking for a purpose-driven career? Come build the future of pharmacy with us.

Job Posting Title

M365/Azure Principal Systems Engineer - Remote

Job Description

We are seeking a Principal Systems Engineer specializing in Microsoft 365 and Azure to join our Enterprise Technology Transformation and Operations team.

If you enjoy being an influencer, shaping strategic direction, and driving innovation across enterprise technology, this role may be exactly what you've been looking for.

In this position, you will serve as the product representative and strategic thought leader for our M365 and Azure ecosystem. You'll collaborate with technology and business stakeholders to define and advance the strategy, roadmap, and architectural vision for Microsoft cloud solutions across the organization.

Responsibilities

  • Represent broad expertise in domain team in technical design and estimating sessions with internal and external IT customers
  • Provide support for and create logical and physical design
  • Analyze and recommend changes to improve efficiency, lower costs, and enhance quality of business applications
  • Establish design patterns used within domain
  • Serve as thought leader and final decision maker in driving teams to conclusions regarding technical solutions
  • Other duties as assigned

Minimum Qualifications

  • Bachelor's degree in computer science or related area of study, or equivalent combination of education and/or relevant work experience; High School Diploma or GED equivalent required
  • 7 years of technical experience in a variety of infrastructure areas
  • M365 Service
  • Azure
  • Must be eligible to work in the United States without need for work visa or residency sponsorship

Must be eligible to work in the United States without the need for work visa or residency sponsorship

Additional Qualifications

  • The ability to understand how M365, Azure and architecture work together.
  • Excellent written, technical, and verbal communication skills
  • Ability and drive to excel in a growing, changing, and collaborative environment
  • Established presenter of technical and non-technical material adapted to the respective audience
  • Ability to transition abstract concepts into technical deployment designs
  • Ability to develop decision criteria and develop unbiased technology comparisons
  • Strong problem-solving and business analysis skills

Preferred Qualifications

  • Master's degree in Computer Engineering
  • ITIL Foundation Certification
  • Experience working in environment with regulatory compliance requirements (HIPAA, PCI, etc.)
  • Previous experience in PBM / health care industry
  • Broad experience in the infrastructure domain working with IT Architecture
  • Understanding of security implications of domain

Every employee must understand, comply with and attest to the security responsibilities and security controls unique to their job, and comply with all applicable legal, regulatory, and contractual requirements and internal policies and procedures

Every employee must be able to perform the essential functions of the job and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions, absent undue hardship. In addition, Prime retains the right to change or assign other duties to this job.

Potential pay for this position ranges from $108,000.00 - $184,000.00 based on experience and skills.

To review our Benefits, Incentives and Additional Compensation, visit our Benefits Page ( and click on the "Benefits at a glance" button for more detail (

Prime Therapeutics LLC?is proud to be an equal opportunity and affirmative action employer. We encourage diverse candidates to apply, and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sex (including pregnancy), national origin, disability, age, veteran status, or any other legally protected class under federal, state, or local law. ?

We welcome people of different backgrounds, experiences, abilities, and perspectives including qualified applicants with arrest and conviction records and any qualified applicants requiring reasonable accommodations in accordance with the law.

Prime Therapeutics LLC is a Tobacco-Free Workplace employer.

Positions will be posted for a minimum of five consecutive workdays.

At Prime Therapeutics (Prime), we are a different kind of PBM. We're reimagining pharmacy solutions to provide the care we would want for our loved ones. That purpose energizes our team and creates limitless opportunities to make a difference.

We know that people make all the difference. If you're ready for a purpose-driven career and are passionate about simplifying health care, let's build the future of pharmacy together.

Prime Therapeutics LLC?is proud to be an equal opportunity and affirmative action employer. We encourage diverse candidates to apply, and all qualified applicants will receive consideration for employment without regard to?race, color, religion, gender, sex (including pregnancy), national origin, disability, age, veteran status, or any other legally protected class under federal, state, or local law. ?? ?

We welcome people of different backgrounds, experiences, abilities, and perspectives including qualified applicants with arrest and conviction records and any qualified applicants requiring reasonable accommodations in accordance with the law.

Prime Therapeutics LLC is a Tobacco-Free Workplace employer.

If you are an applicant with a disability and need a reasonable accommodation for any part of the employment process, please contact Human Resources at 1.866.469.1257 or email [email protected].

If you have questions about this posting, please contact [email protected]
Posted 2026-03-03

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