Postdoctoral Research Associate - Structural Biology

A postdoctoral position is available in the laboratory of Margaret Stratton ( at the University of Massachusetts Amherst, Department of Biochemistry and Molecular Biology. We seek a motivated and creative scientist to lead projects at the interface of structural biology, biochemistry, and cell signaling, with a particular focus on protein kinases and phosphorylation-dependent regulatory mechanisms. Our work aims to uncover the molecular basis of signaling processes that control neuronal function, fertility, and human disease.

The successful candidate will join a collaborative and well-supported research environment with access to state-of-the-art resources in structural biology, including single-particle cryo-electron microscopy, protein biochemistry, and quantitative approaches to studying protein structure and function. This position offers the opportunity to drive independent, mechanistic projects, develop new experimental approaches, and contribute to high-impact publications.

Essential Functions

Perform research in the area of structural biology, protein purification, and assay development.

Write reports and/or papers on completed research in cooperation with professorial supervisor.

Maintain literature awareness of research area.

Present research results orally to professional groups.

Participate in group and divisional seminar in field(s) of study.

Interact collegially with others in the laboratory, the department, and elsewhere at the University.

Collaborate with professorial supervisor in the preparation of research materials.

Maintain laboratory apparatus as applicable in the best possible order; look up catalog numbers and cost of needed research items.

Train junior personnel in basic laboratory methods.

Other Functions

Work collaboratively and effectively to promote teamwork, equality and inclusiveness.

Work in partnership with colleagues within the CNS community and across the campus to support the Dean’s strategic priorities.

Perform other duties as assigned in support of the mission and goals of the College of Natural Sciences.

Minimum Qualifications

Ph.D. in structural biology, biochemistry, biophysics, or a related field.

Strong background in protein expression, purification, and biochemical characterization.

Interest in mechanistic biology and signaling systems.

Strong organizational, communication, and problem-solving skills.

Ability to work both independently and collaboratively.

Preferred Qualifications

Experience in cryo-EM, X-ray crystallography, or related structural approaches is preferred.

Additional Details

At UMass Amherst and in the College of Natural Sciences, we strive to be a community where every individual feels a sense of belonging, where every individual is included, and where every individual is valued. These values and goals are reflected in the College of Natural Sciences’ Inclusive Excellence framework and in the UMass Amherst’s For the Common Good: 2024–2034 Strategic Plan.

Working Conditions

Work is performed in a laboratory or healthcare setting and may involve exposure to chemicals or infectious diseases. Requires standing for extended periods of time and/or use of protective gear.

Work Schedule and Work Arrangement

Monday-Friday, 40 hours per week. Depending on experimental schedules, weekend or evening work may be required.

Tentative start date September 1, 2026.

Salary Information

Salary minimum is determined by collective bargaining agreement based on years of experience. Salary may exceed the floor and will be determined by the PI (final salary will be stated in offer letter).

Current floors based on 100% time, 40 hours/week:
0-2 years $62,838
3-4 years $66,287
5+ years $71,033

Special Instructions for Applicants

Along with the application, please submit a cover letter, CV (including a publication list), and contact information for three (3) professional references. Apply at:

Submissions received before July 10, 2026 , will receive full consideration, but the review of applications will continue until the position is filled.

This position will remain open for the time period required by any applicable collective bargaining agreement and will continue until a suitable candidate pool is identified. Interested applicants are strongly encouraged to apply early.