Principal Research Associate, Mass Spectrometry

Our Culture: Why work with us?

At Foghorn Therapeutics, we believe in “People First, Mission Always.”

We put “People First” because we know our people are the key to everything we will accomplish. We value the diversity of background, ideas, perspectives and experiences that our team members bring to Foghorn Therapeutics – demonstrated by our community speaking more than 22 languages and representing over 24 nationalities. We value our teammates as people, not just as employees – validated by our actions that let our people know that we care about them, their families, and their lives.

We say “Mission Always” because we know a relentless commitment to our mission will make a difference in the lives of others. We believe our success will come from evaluating the data to follow the science. We work hard to develop a new class of therapies that could improve the lives of people with diseases including cancer and immune disorders.

Our culture is focused on succeeding through the evaluation of data, not people. And in that, relationships can flourish and develop.

Our Science:

The groundbreaking science behind our therapies continues to yield vital insights into diseases that have confounded physicians and researchers. Our core scientific approach is centered on the chromatin regulatory system, which opens and closes the right sections of DNA at the right time. Breakdowns in the chromatin regulatory system lead to a wide range of diseases, including cancer, autoimmune and inflammatory diseases, and impact millions of people. Targeting chromatin regulatory system may therefore provide innovative and potential therapeutics to treat those diseases.

Our proprietary Gene Traffic Control® platform is a powerful tool for understanding and modulating the chromatin regulatory system. We are pursuing multiple treatments for breakdowns in this system. We are the only company with the ability to study and target the chromatin regulatory system at scale, in context, and in an integrated way.

Job Summary

This role will support drug discovery efforts through research‑driven, MS–based analytical method development and deep scientific problem‑solving. It will contribute to advancing discovery programs through hands-on operation of instrumentation, development and execution of analytical workflows, and close collaboration with cross-functional scientists across research teams.

Responsibilities

• Perform mass spectrometry–based analyses (e.g., proteomics, intact MS) to characterize small molecules, protein interactions, and other targets relevant to drug discovery programs.
• Operate, maintain, and troubleshoot analytical instrumentation, including LC-MS and related platforms.
• Develop, optimize, and execute analytical methods and exploratory assays, to support compound characterization, screening activities, and project workflows.
• Analyze and interpret experimental data, prepare summaries, and communicate results to cross-functional project teams.
• Collaborate with scientists across chemistry, biology, and pharmacology to advance discovery programs and provide mass spectrometry expertise.
• Contribute to experimental planning, documentation, reporting, and ownership of analytical workflows supporting research activities.

Requirements

Qualifications

• Bachelor’s or Master’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
• 3+ years of relevant laboratory experience in mass spectrometry, biochemistry, or analytical chemistry in a drug discovery, pharmaceutical, or biotechnology setting.
• Experience operating LC-MS, LC-MS/MS, or related analytical instrumentation, with a strong interest in hands-on instrument operation, maintenance, and troubleshooting.
• Demonstrated experience in research‑focused experimental work, such as assay development, method refinement, or troubleshooting complex datasets, beyond analytical testing.

• Preferred
• Experience developing and optimizing LC‑MS analytical methods, including innovating new research assays, adapting techniques to novel targets, or working through complex, non‑routine analytical challenges.
• Familiarity with intact MS, proteomics, or related mass spectrometry workflows.
• Experience with software tools for MS data processing and analysis.

Benefits

Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:

• Highly competitive and inclusive medical, dental and vision coverage options
• FSA and HSA for medical expenses and dependent care expenses
• Free premium access to fitness, nutrition, and mindfulness classes
• Unlimited paid time off policy
• Discretionary winter shut down
• Generous Paid Leave offerings, including 12 weeks of 100% paid parental leave
• Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
• Free parking or subsidized commuter passes
  
  

Foghorn Therapeutics is a smoke-free, alcohol-free and drug-free work environment.

Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.