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Vice President, Global Medical Affairs - Pediatric Neurology

Stoke Therapeutics
Cambridge, MA
About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

Stoke’s initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency).

Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.

Position Purpose:

The Vice President, Global Medical Affairs, will be an individual contributor role with key strategic leadership responsibilities to inform and guide clinical, medical affairs and commercial work across genetic developmental and epileptic encephalopathy (DEE) indications. This individual will serve as a medical expert, building and maintaining strong relationships with internal functions and with external key opinion leaders, healthcare professionals, and patient advocacy groups. They will collaborate actively with clinical development and biostatistics in the design of clinical studies and actively guide analysis and interpretation of data to ensure the safe and effective use of our therapies, generating real-world evidence, and contributing to the overall success of our mission. This position will report into SVP Global Medical Affairs.

Key Responsibilities:

  • Collaborate closely with Medical Affairs Field Medical team to establish and maintain strong scientific relationships and collaboration with key experts and investigators in pediatric developmental and epileptic encephalopathies.
  • Plan and execute ongoing advisory and strategic working groups to gather expert advice to guide strategic decision-making and medical affairs work.
  • Collaborate closely with clinical development to engage with clinical experts to guide clinical study design and execution of clinical trials.
  • Represent Stoke in presentation of clinical data at scientific conferences, medical meetings, and other external events.
  • Provide medical expertise in close collaboration with clinical development, biostats, HEOR and medical affairs to critically interpret clinical data and define product profile.
  • Assist medical communications and investigators in the development and publication of important findings to advance clinical and scientific understanding in defined areas.
  • Provide medical expertise and support to internal stakeholders, including commercial, clinical development, regulatory, and market access teams.
  • Contribute to the development of medical communication and education materials, including scientific abstracts, manuscripts, and slide decks.
  • Provide expertise in delivering medical training to internal staff in support of onboarding and ongoing education.
  • Facilitate interdisciplinary collaboration to enhance patient experience, including working with non-physician providers, nurses, pharmacists, office staff, and therapists.
  • Ensure compliance with all relevant regulatory guidelines and ethical standards in medical affairs activities.
  • Monitor and analyze the competitive landscape and emerging scientific trends in pediatric epilepsy.

Required Skills & Experience:

  • MD/DO degree required.
  • Board certification in Neurology, Pediatrics, or a related specialty is highly preferred.
  • Minimum of 10-15 years of combined clinical and pharmaceutical or biotechnology industry, with a significant focus on pediatric epilepsy or rare neurological diseases.
  • Deep clinical experience and expertise in pediatric epilepsy is essential.
  • Excellent communication, presentation, and interpersonal skills, with the ability to effectively engage with diverse stakeholders.
  • Demonstrated ability to build and maintain strong relationships with key opinion leaders and external experts.
  • Thorough understanding of regulatory requirements and ethical guidelines governing medical affairs activities.
  • Ability to travel globally as required.

Location(s):

Stoke is located in Bedford, MA. This position is remote position.

Travel:

This position will require approximately 50-70% travel.

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do.

Benefits & Compensation:

At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center.

For more information, visit stoketherapeutics.com or follow the company on X at @StokeTx.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.
Posted 2025-10-21

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