Manager, Pharmacometrician

**Use Your Power for Purpose** You will have a profound impact on improving patients' lives by ensuring our evidence is scientifically robust and providing unbiased, medically essential expertise. Your role is vital in connecting sound scientific evidence with practical medical insights to enhance health and treatment outcomes. By bridging data gaps and empowering healthcare decisions regarding the safe and appropriate use of medicines, you will contribute significantly to patient care and treatment efficacy. In addition to professional challenge, we offer a culture that supports and encourages ideas, and recognizes individual contribution. **ROLE SUMMARY:** + Develops model informed drug development (MIDD) plans across projects and disease areas in order to optimize prospective studies, inform drug development strategy and project decision-making, in collaboration with partners. + Conducts and reports quantitative analyses which integrate knowledge of pharmacokinetics, pharmacodynamics, patient characteristics, and disease states to optimize doses, dosage regimens and study designs throughout clinical drug development. + Identifies opportunities where modeling and simulation can advance the understanding of pharmacological activity, efficacy and safety. + May help in providing support and/or development of quantitative methodology, pharmacometrics tools, software, hardware, and related business processes **ROLE RESPONSIBILITIES:** + Responsible for the planning and execution of relevant quantitative analyses which may include population pharmacokinetics, pharmacokinetics/pharmacodynamics, exposure response, disease progression modeling, model-based meta-analysis, quantitative knowledge management, decision analysis, and MIDD strategy in collaboration with partners. + Prepares formal presentations and written reports to Pfizer standards. + Provide Quantitative Clinical Pharmacology expertise on multidisciplinary development teams, working closely with clinical pharmacologists, clinicians and statisticians to create clinical development plans that include assessments of a drug's efficacy, safety, and commercial viability. + May contributes with project teams/partners to regulatory documents. + Stays abreast of literature, government guidelines, and internal guidance as relates to pharmacometrics and MIDD, including internal SOPs and regulations in order to be a team resource of pharmacometric knowledge and applications. + Contribute to the development or improvement of our tools, processes and methodology, including involvement in internal cross-functional workgroups or initiatives, external alliances or committees, consortia and academic relationships. **BASIC QUALIFICATIONS:** + PhD or equivalent degree with 0-3 years of relevant experience. Strong quantitative skills (e.g., pharmacometrics, pharmacokinetics, mechanistic modeling/systems pharmacology, literature meta-analyses, clinical trial simulations, statistics) are required. + Good understanding of Pharmacokinetics, Pharmacodynamics and Statistical Principles + Expertise in analysis and programming software (e.g., Nonmem, R). + Experience in pharmacometric analyses + Drug development and/or regulatory experience + We encourage applicants from different disciplines including clinical pharmacology, engineering, biostatistics, medicine, biology, etc. + Good communication skills (written, oral presentation). **PREFERRED QUALIFICATIONS:** + Experience using NONMEM, R and/or PsN software is preferred. + Publications in relevant discipline **PHYSICAL/MENTAL REQUIREMENTS:** + Ability to perform mathematic calculations and data analysis. **ADDITIONAL JOB DETAILS:** + Last date to apply is December 18, 2025 + Work Location Assignment: **This is a hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week.** The annual base salary for this position ranges from $102,900.00 to $171,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. **Sunshine Act** Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. **EEO & Employment Eligibility** Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [email protected]. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. Medical