Associate Director, CF Lead, US HEOR

Job Description

Vertex Pharmaceuticals is seeking an Associate Director to join the US Health Economics & Outcomes Research (HEOR) team to develop and execute on the HEOR strategy and related tactics to support the commercialization of the Vertex cystic fibrosis portfolio in the United States (US). This person will work in a highly cross-functional matrix team environment, serving as the US HEOR lead for our CF Portfolio and interfacing with Market Access, Public Affairs, and Medical teams to help develop and execute on a seamless plan for continuing to communicate the holistic and real-world value of our 5 CF medicines to various stakeholders, including payers and policymakers. This role will also be required to support similar projects in our newly-launched non-opioid Pain program. This person is expected to exhibit a strong sense of urgency to achieve corporate objectives while maintaining the highest ethical, regulatory and scientific standards. This position reports to the Senior Director of US HEOR.



Key Responsibilities:

• Represent HEOR at US cross-functional forums

• Develop and execute a cross-functionally aligned HEOR plan for the Cystic Fibrosis portfolio, with a focus on communication of real-world evidence

• In partnership with Market Access and Medical Affairs, develop and update innovative external customer-facing value demonstration tools that meet regulatory standards and train and certify appropriate field teams (e.g., field HEOR, payer account team) for effective and compliant delivery

• Lead the economic submission development and serve as a key reviewer for upcoming Canadian HTA submissions for TRIKAFTA and ALYFTREK age expansions

• Work closely with Global HEOR team to inform evidence generation and publication plans from the US perspective and to ensure timely translation of HEOR studies for external value communication to customers

• Occasionally engage directly with external customers (e.g., payer accounts, health systems, policymakers) to discuss HEOR data and represent Vertex as needed to achieve business objectives

• Lead and execute collaborative research with US external customer entities (e.g., payers, health systems) in a compliant manner

• Support the Pain program on key cross-functional projects articulating the real-world clinical and economic value of JOURNAVX (a novel non-opioid Nav1.8 inhibitor launched in January 2025 for acute pain) to payers, health systems, and policy stakeholders
  
  
  
  Minimum Qualifications

• Advanced degree (e.g. PhD, MD, MPH, or PharmD) in a scientific discipline. A clinical degree must be supplemented with advanced training in a HEOR-related discipline (e.g., MPH/MS, PhD, HEOR fellowship)

• Typically requires 8 years of experience in HEOR or related discipline

• Previous biopharma and/or HEOR consulting experience strongly preferred

• US Market experience required. Rare disease experience a plus

• Demonstrated capabilities in interpreting and applying the 2018 FDA Payor Guidance to payer communication in the US

• A track record of peer-reviewed publications demonstrating experience in COAs, observational research, and/or health economic modeling

• Strong communication skills, both verbal and written, including the ability to effectively present to both internal and external audiences

• Results oriented and excellent analytic and project management skills

• A strong sense of urgency and commitment to patients

Pay Range:

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid : work remotely up to two days per week; or select
2. On-Site : work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]