Scientist II (R&D)
The BioDesign Protein & Cell Engineering group is seeking a creative and self-motivated scientist to contribute to our mission to design and develop medicines to transform patients lives. The successful candidate will play a key role in enabling the generation of antibodies and antibody-oligonucleotide conjugates intended to improve the delivery of therapeutic oligonucleotides to target tissues. Primary responsibilities will include antibody expression, cell line generation, target binding and assessment of gene knockdown.
Primary responsibilities will include:• Stable cell line generation
• Antibody expression in mammalian cells in shake flask cultures up to 3 liter
• Plasmid production
• qPCR to assess target knockdown in cell lines and tissue lysates
• Assessment of antibody binding to target by flow cytometry Required Skills:
• Mammalian tissue culture experience
• Excellent written and verbal communication, documentation and record-keeping skills
• MS in Biology, Molecular Biology, Cell Biology, Biochemistry or related field with 3 or more years of experience (Candidates with more or less experience will be considered and are encouraged to apply) Preferred Skills:
• Experience with protein or antibody expression in CHO cells by transient transfection
• Experience with generating stable CHO cell pools secreting recombinant proteins or antibodies
• Experience with large scale expression or bioreactor handling
• Experience with cell engineering, stable cell line generation
• Nucleic acid quantitation by qPCR or ddPCR
• Flow cytometry sample preparation and data analysis
• Immunoassay techniques Eg. MSD, Elisa
• Antibody purification Pay ranges between $42-49/hr based on experience
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