Scientist II

About the job
*** is a leading company in Global Healthcare that discovers, develops, produces, and markets innovative therapies to help protect health and enhance people's lives. We are seeking a highly motivated in-vivo pharmacologist to join the Type 2 Immunology Cluster within the Immunology and Inflammation Therapeutic Area located in Cambridge, MA. The ideal candidate will possess a strong background in in-vivo pharmacology, contributing technical skills and functional knowledge. The candidate will also be involved in the design, overall conduct, and the reporting of in-vivo pharmacology study results to project teams. The position is a hands-on, laboratory-based role that requires strong communication skills, attention to detail, a results-driven way of working, and ability to work both individually and in a team environment, and to work across functions. A successful candidate is expected to analyze, record and report data, be able to develop and learn new techniques, and be able to multi-task between multiple projects.


Main Responsibilities:
• Responsible for designing and performing in-vivo pharmacology experiments in support of project team goals. This includes study design, data collection and recording, communication of results, and report writing.
• Summarize and present study data to project teams within established timelines.
• Generate specific pharmacology reports based on studies performed to support IND submission.
• Capacity to use established procedures and methodologies with the ability to transform Client approaches into routine practice.
• Use detailed knowledge of state-of-the-art tools and approaches to enhance in vivo evaluation of Client therapeutics mechanism of action and/or identify new targets.
• Identify and develop ex vivo analytical tools that can be used to maximize the read-outs from in vivo studies
• Must be a technical contributor.
• Ability to troubleshoot experiments.
• Support the development of disease relevant in-vivo models.
• Must be well organized and detail oriented.
• Must have meticulous record keeping skills according to *** quality guidelines. Maintain a thorough and compliant laboratory notebook.
• Must adhere to all federal, local, and *** animal welfare guidelines.
• Must be capable of working alone and in a team environment.
Qualifications:
• Deep knowledge of immunology, mechanistic understanding of autoimmune or inflammatory pathologies. Proficiency in establishing in vivo PK/PD and efficacy models of immunology/autoimmune diseases (e.g. DTH, DSS, T cell transfer model, ovalbumin induced asthma...).
• Extensive in vivo pharmacology expertise in working with rodent inflammatory models and in molecular, cellular biology and immunological assays (e.g. Flow cytometry, cytokine measurement) required. Well-established hands-on experience with in vivo dosing, bleeding, and handling techniques and proficiency in basic surgical techniques.
• Experience with compound or reagent preparation.
• Ability to work under moderate supervision with regular review of results and methods utilized.
• Ability to present study related results to project teams.
• Proven ability to work in a dynamic, customer-focused and results-oriented environment.
Education and Experience:
Master's Degree plus a minimum of 3 years of relevant research experience in a biopharmaceutical setting OR a Ph.D. in Immunology, Pharmacology with relevant research experience in academic facility or biopharmaceutical setting.