Senior Manager, Bioinformatics Operations

Kforce is working with a client located in Marlborough, MA that is seeking a highly skilled and motivated Senior Manager of Bioinformatics Operations to lead a regional team focused on delivering clinical-grade bioinformatics applications that drive precision diagnostics. This is a hands-on leadership role for someone who thrives in a fast-paced, regulated environment and is passionate about operational excellence in genomics. Summary: As the regional lead, you will oversee the development, validation, and support of automated bioinformatics pipelines used in genetic laboratories. You will work closely with cross-functional teams-including lab scientists, product owners, IT, and bioinformatics engineers-to ensure high-quality, stable, and efficient applications that meet clinical turnaround times and compliance standards. Key Responsibilities:

• Lead and mentor a team of 5-7 bioinformaticians and contractors, fostering accountability and growth
• Manage daily operations of bioinformatics pipelines, ensuring service levels and turnaround targets are met
• Collaborate with lab operations to support sample processing and troubleshoot production issues
• Oversee incident response, system health monitoring, and performance metrics
• Drive CI/CD practices and workflow orchestration using tools like Nextflow, Snakemake, and ServiceNow
• Maintain data integrity, compliance documentation, and secure archival of clinical data
• Partner with engineering teams to enhance automation and implement data-driven process controls
• Support software version upgrades, tech transfers, and product launches in collaboration with R&D
• Align with other regional managers to standardize practices and share operational insights
• Implement training frameworks and competency assessments to upskill team members
• 7+ years of experience in bioinformatics, software engineering, or related fields
• Strong technical background in Python, R, Shell scripting, SQL, and AWS
• Experience with sequence aligners, variant callers, and interpretation tools
• Proven leadership in managing technical teams and delivering production-grade solutions
• Familiarity with regulated environments (CAP, CLIA, FDA) and handling sensitive patient data
• Excellent communication, project management, and problem-solving skills
• Comfortable working across abstraction levels-from strategy to technical execution

Preferred Experience:

• MSc or PhD in Bioinformatics, Computer Science, or related discipline
• Agile certification and experience with international teams
• Experience with LIMS, variant interpretation platforms, and cloud migration

This is a strategic and impactful role for a bioinformatics leader who is ready to shape the future of clinical genomics operations. You will be part of a mission-driven organization that values innovation, collaboration, and continuous improvement. Benefits include comprehensive health coverage, paid time off, retirement plans with company match, education assistance, and career development programs.