Advisor / Sr. Advisor - Molecular Engineering Gene Therapy

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Join the rapidly expanding Lilly Gene Therapy team at Eli Lilly. We invent, characterize, and advance novel gene therapy reagents for a wide range of clinical applications, working cross-functionally across disease areas and platforms. Our goal is to deliver on the promise of gene therapy for patients worldwide.

• Design, build and test novel CAR constructs by combining modular protein domains to support discovery-stage cell therapy programs
• Apply molecular biology methods and protein engineering strategies to enhance construct performance
• Design and manage large-scale construct libraries (arrayed and pooled) for discovery campaigns
• Partner with LVV production teams to enable high-throughput testing of construct panels
• Work with broader teams to quantify in vitro and in vivo outcomes from produced constructs
• Work cross-functionally with Lilly’s expertise in Immunology, Oncology, Computational Biology, and Genomics to advance novel cell therapy programs
• Partner with translational teams and CROs to test engineered CARs in primary immune cells, in vitro functional assays, and in vivo models

• PhD in biology, molecular biology, or related scientific field.

• Strong expertise in molecular biology techniques, including cloning, mutagenesis, PCR/qPCR/ddPCR, and sequencing
• Experience in protein engineering approaches such as codon optimization, linker design, and modular domain assembly
• Experience with library-scale cloning or mutagenesis approaches (Golden Gate, Gibson, or similar)
• Familiarity with computational protein design tools is a plus
• Experience with primary cell engineering or in vivo models is a plus
• Excellent problem-solving skills and ability to troubleshoot complex issues
• Strong communication and collaboration skills

• This role may require up to 10–15% travel for conferences or training. Location: 15 Necco Street, Boston Seaport, MA 02210.

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Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $133,500 - $217,800.

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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