Postdoctoral Associate - Cardiovascular Disease Initiative (CVDI)

The Broad
Institute of MIT & Harvard , a world leader in genetic research, is
looking for an exceptional postdoctoral candidate to join the Cardiovascular
Disease Initiative (CVDi) led by Dr. Patrick Ellinor. The successful candidate
will join an interdisciplinary team of computational biologists, laboratory
scientists, clinicians and faculty members. We are interested in understanding
the molecular mechanisms of genetic cardiovascular diseases. We apply
cutting-edge technologies in functional genomics to study genes associated with
increased risk of cardiovascular diseases. The team works together to identify
and validate new genes associated with cardiovascular disease including atrial
fibrillation, heart failure and coronary artery disease, and to launch new
therapeutic drug discovery programs based on these human genetic insights.

The candidate will work on NIH funded as well as
exploratory academic projects and will conduct experimental research studies at
the bench, supervise a research associate, and contribute to therapeutics
project(s) targeting cardiovascular disease.

Example workstreams for projects include: designing
high-throughput CRISPR-based screens in hPSC-derived cells, characterizing gene
functions in hPSC-derived cells, and validating potential drug targets. Other
tasks include developing assays for small molecule drug discovery, generating
datasets using single-cell RNA sequencing, and validating gene and protein
expression with immunofluorescent techniques and in situ hybridization.
Additionally, work may involve creating and validating in vitro and in vivo disease
models and conducting experiments to understand target gene functions.

This is an excellent opportunity for a highly motivated candidate interested in
exploring the early stages of drug development in a vibrant atmosphere.

REQUIREMENTS

● Ph.D. in Biology (Developmental, Molecular, Cellular Biology), Genetics,
Biochemistry, or related life science field with 0-2 years of experience in
academic setting

● At least one first author publication in a basic/mechanistic area of biology

● Experience in working with pluripotent stem cells, CRISPR genome editing,
single-cell RNA sequencing, cell-based imaging techniques

● Hands-on experience in cellular assay development and proficiency with
standard assay formats (e.g. flow cytometry, imaging, luminescence-/fluorescence-based
cellular readouts, immunohistochemistry) in primary and cultured cells

● Experience with cardiac electrophysiology is preferred

● Experience with mouse models especially in the cardiovascular field is a plus

● Experience with computational skills is a plus

● Ability to develop research plans for executing strategy, operate and
maintain equipment, and perform laboratory work, with complete independence

● Track record of working on complex problems, and ability to integrate data
from multiple disciplines

● Strong interpersonal, influencing, and collaboration skills to work in a
team-oriented, matrix environment, and the ability to work through conflicts

● Outstanding verbal and written communication abilities

● Ability to adapt to and effectively manage changes in a fast paced and
dynamic environment

● A passion and curiosity for science and sense of urgency to find new
medicines to benefit patients

The successful candidate will be a results-focused, team-oriented, creative,
bench scientist, able to excel in a fast-track environment. The candidate must
be self-motivated, detail-oriented and exhibit strong problem-solving skills.
In addition, the successful candidate should be a clear and effective
communicator, demonstrating strong interpersonal skills to enable collaboration
with project teams, peers, and management, for identifying and achieving
research goals.

70,000 - 92,667 Usd Annual

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law. At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
Should you need a reasonable accommodation to complete the application or interview process, please contact [email protected] for assistance.