Postdoctoral Researcher

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Job Title: Postdoctoral Research Fellow position available in X-ray Crystallography and Cryo-EM of Proteins Regulating Triglyceride Metabolism.

About Us: Join our dynamic research team dedicated to unraveling the mysteries of triglyceride metabolism. We are seeking a talented and motivated Postdoctoral Scientist to lead cryo-electron microscopy (cryo-EM) and X-ray crystallography studies on proteins involved in the regulation of triglyceride metabolism. This position provides a unique opportunity to contribute to cutting-edge research with direct implications for metabolic health. The Birrane Lab is located at the Beth Israel Deaconess Medical Center and Harvard Medical School in the Longwood area of Boston, Massachusetts. We have regular access to synchrotron beamlines (NSLS-II, APS) and state-of-the-art cryo-EM facilities at Harvard Medical School and MIT.

Position Overview: As a Postdoctoral Fellow, you will be at the forefront of our efforts to understand the structural basis of proteins influencing triglyceride metabolism. Utilizing your expertise in Protein expression and purification, X-ray crystallography and/or cryo-EM, you will play a crucial role in unraveling the molecular mechanisms that underlie the regulation of triglyceride homeostasis. This position offers a stimulating and collaborative environment for scientific exploration.

Key Responsibilities:

• Conduct X-ray crystallography experiments to determine high-resolution structures of proteins involved in triglyceride metabolism.

• Apply cryo-EM techniques for structural analysis of protein complexes and interactions.

• Work collaboratively with the research team to design and execute experiments.

• Analyze and interpret experimental data, contributing to the preparation of scientific publications.

• Stay abreast of the latest developments in structural biology and lipid metabolism.

Preferences:

• Ph.D. in Structural Biology, Biochemistry, or a related field.

• Proven expertise in X-ray crystallography and/or cryo-EM techniques.

• Excellent analytical and problem-solving skills.

• Effective communication skills and the ability to work collaboratively in a team.

• Experience in protein expression, purification, and biochemical characterization.

• Familiarity with software tools for data processing and structure determination.

• Strong background in proteins related to lipid metabolism or cellular signaling.

• Track record of successful contributions to peer-reviewed publications.

Job Description:
Primary Responsibilities:
- Abides by the institutional policies of BIDMC relating to health and safety, equality of opportunity and data storage and management. (essential)

- As a member of the research team, actively pursues research under the supervision of a principal investigator while developing skills for independent work. (essential)

- Receives training in and performs duties contributing to the investigational work of the team including formulation of research questions and design, conduct of experiments, and evaluation of results. (essential)

- Prepares and publishes scientific manuscripts under direction of PI. (essential)

- Develops expertise in desired lab skills/informatics/ physics/clinical research. Develops proficiency with research tools and equipment. Develops ability to work with more independence as the fellowship progresses (essential)

- Develops new ideas that promote current research; brings new expertise to the research program. (essential)

- teaching skills and provide supervision of students and their projects when appropriate. (essential)

- Engages in collaborative meetings with other research groups. Attends and leads scientific seminars. (essential)

- Learns to identify, acknowledge and correct deficiencies in one's own performance. (essential)

- Under the direction of PI, pursues/secures independent funding near the end of the fellowship. (essential)

Required Qualifications:

• Doctoral Degree or M.D.
• 0-1 year of postdoctoral research experience in academic or industrial lab setting, and/or teaching assistantship in a university setting, and/or residency, and/or clinical duties beyond that of the qualifying doctoral degree.

Competencies:
Decision Making: Ability to make decisions that are guided by general instructions and practices requiring some interpretation. May make recommendations for solving problems of moderate complexity and importance.
Problem Solving: Ability to address problems that are varied, requiring analysis or interpretation of the situation using direct observation, knowledge and skills based on general precedents.
Independence of Action: Ability to follow precedents and procedures. May set priorities and organize work within general guidelines. Seeks assistance when confronted with difficult and/or unpredictable situations. Work progress is monitored by supervisor/manager.
Written Communications: Ability to summarize and communicate in English moderately complex information in varied written formats to internal and external customers.
Oral Communications: Ability to comprehend and communicate complex verbal information in English to medical center staff, patients, families and external customers.
Knowledge: Ability to demonstrate in-depth knowledge of concepts, practices and policies with the ability to use them in complex varied situations.
Team Work: Ability to lead collaborative teams for larger projects or groups both internal and external to the Medical Center and across functional areas. Results have implications for the management and operations of multiple areas of the organization.
Customer Service: Ability to provide a high level of customer service and staff training to meet customer service standards and expectations for the assigned unit(s). Resolves service issues in the assigned unit(s) in a timely and respectful manner.

Physical Nature of the Job:
Light work: Exerting up to 20 pounds of force frequently to move objects. Some elements of the job are sedentary, but the employee will be required to stand for periods of time or move throughout the hospital campus.

Pay Range:
$60,320.00 USD - $90,001.60 USD

The pay range listed for this position is the annual base salary range the organization reasonably and in good faith expects to pay for this position at this time. Actual compensation is determined based on several factors, that may include seniority, education, training, relevant experience, relevant certifications, geography of work location, job responsibilities, or other applicable factors permissible by law.

As a health care organization, we have a responsibility to do everything in our power to care for and protect our patients, our colleagues and our communities. Beth Israel Lahey Health requires that all staff be vaccinated against influenza (flu) as a condition of employment.

More than 35,000 people working together. Nurses, doctors, technicians, therapists, researchers, teachers and more, making a difference in patients' lives. Your skill and compassion can make us even stronger.

Equal Opportunity Employer/Veterans/Disabled