Postdoctoral Research Fellow - Eck Lab

Overview

The Eck Lab is dedicated to advancing our understanding of protein kinase regulation and cellular signal transduction through structural, biochemical, and biophysical approaches. Our research aims to leverage these insights to develop novel anti-cancer drugs. We focus on systems such as RAF-family kinases, EGFR mutations in lung cancer, and JAK2 dysregulation in myeloproliferative disorders.

We are seeking a Postdoctoral Research Fellow to join our dynamic team. The successful candidate will engage in cutting-edge research to explore protein kinase regulation and contribute to the development of innovative cancer therapies. This role offers the opportunity to work in a collaborative, interdisciplinary environment with access to state-of-the-art facilities.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

• Conduct research on protein kinase regulation and cellular signal transduction pathways.
• Utilize structural methods such as X-ray crystallography, cryo-EM, or NMR for protein structure elucidation.
• Perform protein expression and purification using mammalian or insect cell systems.
• Develop and automate kinase enzymology assays and conduct enzyme kinetics, binding studies, and calorimetry.
• Collaborate with interdisciplinary teams, including disease-focused scientists and medicinal chemists, to translate structural insights into therapeutic strategies.
• Present research findings through oral presentations and written publications.

Qualifications

• Ph.D. or equivalent doctoral degree in biochemistry, molecular biology, or a related field.
• Strong background in protein biochemistry, with expertise in protein expression and purification.
• Experience with structural methods (X-ray crystallography, cryo-EM, or NMR) is highly desirable.
• Proficiency in basic molecular biology techniques.
• Excellent oral and written communication skills.
• Strong organizational and interpersonal skills.
• Creative and independent thinker with a passion for basic research.

Facilities and Environment:

• Access to state-of-the-art facilities, including cryo-EM, X-ray crystallography, and mass spectrometry.
• Collaborative and interdisciplinary research environment within Dana-Farber’s Longwood Center.
• Affiliation with the Chemical Biology program at Dana-Farber and the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.