Principal Scientist
job summary:
Join a top-tier global pharma leader in Cambridge, MA, as a Bench Scientist Biologist - Level 3. This is a high-impact opportunity to lead the development of scalable, cell-based assay platforms for evaluating multi-epitope mRNA construct designs. You will play a pivotal role in optimizing mRNA vaccine constructs within a cutting-edge, high-throughput environment.
location: Cambridge, Massachusetts
job type: Contract
salary: $83.00 - 84.47 per hour
work hours: 9 to 5
education: Doctorate
responsibilities:
- Lead the development of cell-based assays to evaluate and rank mRNA construct designs, focusing on expression proxies and T cell activation.
- Provide technical leadership in complex flow cytometry, including multi-color panel design, acquisition, gating standards, and troubleshooting.
- Partner with Molecular Biology and RNA teams to translate assay readouts into actionable mRNA design recommendations.
- Establish robust, high-throughput workflows (96/384-well formats) using primary immune cells and engineered cell lines.
- Ensure data integrity and operational compliance while mentoring team members on new assay capabilities and SOPs.
qualifications:
Required:
- PhD in Immunology, Cell Biology, Molecular Biology, or a related field with 3+ years of post-doc/industry experience (or MS with 8+ years).
- Deep hands-on expertise in flow cytometry (design through analysis) and building reproducible assays.
- Strong knowledge of RNA biology, cloning, and mRNA vaccine principles.
- Extensive experience working with immune or engineered cell lines.
- Practical experience with microscopy-based assays (confocal or high-content imaging) for cellular readouts.
- Experience with high-throughput screening and liquid-handling platforms (e.g., Tecan, Hamilton).
- Expertise in T cell functional assays and antigen processing pathways.
skills: Molecular Biology, Immunology, Cell Biology, Laboratory Information Management Systems (LIMS), Flow Cytometry, SOP Development
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status. At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact [email protected].
Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including: medical, prescription, dental, vision, AD&D, and life insurance offerings, short-term disability, and a 401K plan (all benefits are based on eligibility).
This posting is open for thirty (30) days. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Recommended Jobs
Floor Supervisor
LIVE THE ISLAND LIFE Tommy Bahama is more than just an island inspired brand, it’s a lifestyle! Live the Island Life as an ambassador of our brand, representing the season’s stylish trends. We l…
DevOps Engineer
Platform Engineer – Travel SaaS A fast-scaling SaaS company in the travel tech space is hiring a Platform Engineer to help build and scale their global infrastructure. This is a high-impact ro…
Service Technician (Springfield)
Overhead Door / Dock Equipment Technician / amazing company, growth, DAY SHIFT, overtime, company vehicle!! This Jobot Job is hosted by: Jillian Morgan Are you a fit? Easy Apply now by clicking …
AI-Driven Internal Tools Product Manager (Full Stack)
A leading technology firm in Massachusetts is looking for an AI-forward Full Stack Product Manager to enhance operational efficiency through AI and automation. This role involves identifying workflow…
Outpatient Physical Therapist
Job Summary: We are seeking a dedicated and energetic Physical Therapist to join our practice. In this role, you will assess, develop, and implement personalized care plans to improve patients’ mo…
*Teaching Fellow 2026-2027*
Description Organization Overview Excel Academy is a network of 5 schools in Massachusetts and Rhode Island that prepares students in grades 5-12 to succeed in high school and college and engage …
Stress Engineer
Position Summary At Babcock Power, we are a driving force in power, committed to shaping the future of energy solutions. Driven by our core values of Teamwork, Integrity, and Performance, we ena…
Social Worker - Care Management
POSITION SUMMARY: The Care Management Social Worker in the Care Management Department works effectively to coordinate discharge planning activities in cases requiring short- and long-term placem…
Warehouse Associate (Full Time, Day Shift)
Shift: Monday - Friday 8:00am - Until task completion Overtime is required based on business needs Pay rate: $20.50 per hour Bonus eligible: No Benefits: Cardinal Health offers a wi…
Registered Nurse, Tri River Family Health, Per Diem
Are you an internal caregiver, student, or contingent worker/agency worker at UMass Memorial Health? CLICK HERE to apply through your Workday account. Exemption Status: Non-Exempt Hiring Range:…