Contract Research Associate

Job Description

Job Description

Repertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer and autoimmune disease. The company was founded on the belief that understanding the repertoire of T cell receptor (TCR)-antigen immune synapses that maintain health and drive disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODETM platform, which allows in-depth characterization of TCR-antigen pairs, and the ability to deploy this information in the form of novel targeted immune medicines to fundamentally reprogram the immune system to kill tumors or induce immune homeostasis.

From its sites in Cambridge, Massachusetts and Zurich, Switzerland, Repertoire’s team is advancing a pipeline of DECODE-enabled immune medicines. For cancer, we are developing a pipeline of TCR bispecifics molecules for treatment of multiple cancer types. Repertoire is progressing through IND-enabling studies with its lead development candidate and is planning to initiate a Phase 1/2 clinical trial in multiple cancer indications. In addition, we are developing a pipeline of mRNA tolerizing vaccines for treatment of autoimmune diseases.

Repertoire was founded in 2019 by Flagship Pioneering and is supported by a strong investor base. The company entered into a collaboration and license agreement with Genentech in April of 2025 to discover and develop innovative T cell-targeted immune medicines for an autoimmune indication. In addition, Repertoire entered a strategic partnership in April of 2024 with Bristol Myers Squibb to develop tolerizing vaccines for up to three autoimmune diseases.

Research Associate (Contract)
Upstream Process Development

Full-Time 3 to 6-Month Contractor On-Site in Cambridge, MA

Repertoire is looking for a highly skilled Research Associate to join the Technical Development (TD) team within the Protein Engineering and Molecular Sciences (PEMS) group for a 6-month contract role. The TD team is engaged in the development of upstream and downstream processes of TCR bispecifics and analytical characterization associated with process development.

The contractor will work at the bench performing basic lab operations including bacterial/mammalian cell culture, clarification, and protein analysis. The candidate will collaborate with a team of scientists and research associates, to support analytical characterization. The contractor will be expected to document the experiments conducted in an electronic lab notebook system, to present the work/findings in internal meetings, and to have good interpersonal, verbal, and written communication skills.

Key Responsibilities

• Preparation of bacterial cultures for production of TCR bispecifics.
• Harvest of inclusion bodies from bacterial pellets.
• Analysis and aliquoting of IB for downstream processing.
• Fermenter set-up, operation, and shutdown.
• Maintenance of CHO cell cultures.
• Transient Transfection of CHO cells for recombinant protein production.
• Characterization of Inclusion Bodies/Mammalian Supernatants by, SDS-PAGE, Western Blot, and Capillary Electrophoresis.
• Characterize purified TCR bispecifics and reagent proteins using SDS-PAGE, analytical SEC and DSF.

Qualifications/Experience

• BS/MS in microbiology, biochemistry, biotechnology or a similar field.
• Experienced utilizing sterile technique to handle liquids.
• Industry experience preferred.
• Experience with mammalian or microbial cell culture and/or protein analytical methods preferred.
• Disciplined in following instructions and protocols while effectively communicating and asking questions as they arise.
• Strong organizational skills along with excellent attention to detail.
• Enjoys working in a collaborative, fast-paced, and quickly changing environment.
• Proficiency in using Lab Notebook Systems.

Repertoire is committed towards social responsibility and developing an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce. We believe in actively pursuing equity in all facets of the work experience at Repertoire. We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.
Repertoire is proud to be an Equal Opportunity Employer.

Recruitment & Staffing Agencies: Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire’s internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.

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