Downstream Purification Scientist
Downstream Purification Scientist needs 2 years of hands-on purification experience in an academic or industry setting
Downstream Purification Scientist requires:
- Hands-on experience in Cesium chloride (CsCl) density gradient ultracentrifugation, ion-exchange chromatography, affinity purification, and tangential flow filtration (TFF), with a strong understanding of purification principles and data analysis.
- Master's degree in biology, biochemistry, chemical engineering, biotechnology, or related field.
- AAV or other viral vector CsCl density gradient and column purification.
- Experience with AKTA systems and Unicorn software.
Downstream Purification Scientist duties:
- Execute purification processes including CsCl density gradient ultracentrifugation, affinity chromatography (e.g., AVB, CaptureSelect), ion-exchange chromatography (AEX, CEX), and other polishing steps.
- Operate AKTA systems (Avant, Pure, or Pilot) for small- to large-scale purification runs. Perform TFF operations for buffer exchange and concentration of intermediate or final products.
- Support experimental design, data collection, and documentation following established procedures and GMP/GLP best practices.
- Assist in troubleshooting and optimization of purification processes.
- Analyze in-process and purified samples using relevant analytical methods (e.g., UV, SDS-PAGE, ddPCR, ELISA, or HPLC).
- Collaborate cross-functionally with upstream, analytical, and manufacturing teams.
- Maintain lab equipment, manage buffers and column inventory, and ensure compliance with safety and documentation standards.
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