Associate Director, Clinical Science

Job Description

Job Description

Job Title:

Associate Director, Clinical Science

Reports To:

Head of Clinical Science

About Solid Biosciences:

Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. The Company is also focused on developing innovative libraries of genetic regulators and other enabling technologies with promising potential to significantly impact gene therapy delivery cross-industry. Solid is advancing its diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. For more information, please visit

Position Summary:

Solid Biosciences is seeking an Associate Director, Clinical Science to support the clinical development of its gene therapy pipeline. This individual will assume key roles in the design, execution, oversight, and analysis of clinical trials with a primary focus on Solid’s lead clinical asset, SGT-003, an investigational next-generation microdystrophin gene therapy for Duchenne muscular dystrophy. As such, a candidate being considered for the role must have experience in the therapeutic area and/or modality.

The Associate Director, Clinical Science position resides within Clinical Development and reports to the Head of Clinical Science. The individual may work in a Hybrid pattern based out of the Charlestown, MA office or may work Remotely if able to normally work Eastern Time business hours. Up to approximately 20% travel will be required.

Key Duties & Accountabilities:

• Contribute to the design, execution, oversight, and analysis of global clinical trials spanning early and late phases
• Ensure studies are conducted in accordance with protocols and regulatory requirements, including monitoring study progress and reviewing study data
• Partner closely with cross-functional teams (including, but not limited to, Clinical Operations, Bioanalytical, Data Management, Biostatistics, Pharmacovigilance, Regulatory, MS&T, Supply Chain, Patient Advocacy) to execute clinical development
• Author sections of study-related documents (e.g., protocols, manuals, IB) and clinical-related documents for regulatory submissions (e.g., briefing books, IND, CTA, CTR, DSUR, CSR)
• Contribute to the Clinical Development Plan and clinical components of the TPP
• Prepare, present, and provide in depth explanation of complex aspects of study protocols and relevant training, when applicable, to clinical trial teams, vendors, and investigative sites
• Support the development of CRFs and associated data review strategy, ensuring that protocol-specific details such as deviations, eligibility criteria, and study assessments are implemented consistently and according to guidelines
• Perform ongoing patient-level data review to identify clinical data insights and potential trends
• Interpret data to produce strategically relevant abstracts, presentations, and manuscripts for scientific, patient advocacy, and/or broader audiences
• Engage with investigators and KOLs to facilitate clinical trial execution, enhance patient recruitment and retention, and effectively disseminate data
• Attend investigator meetings, clinical advisory boards, scientific meetings, patient advocacy meetings, and/or congresses to support clinical programs as needed
• Work effectively within highly cross-functional teams, emphasizing strategic and proactive communication

Core Competencies:

• Research background with the ability to think creatively to address complex situations
• Strong oral and written communication skills
• Ability to deliver well-organized, thoughtful presentations to varied audiences (scientific, non-scientific, senior management)
• Exceptional attention to detail and organization
• Highly flexible and adaptable to a changing biopharma landscape
• Ability to develop collaborative working relationships with cross-functional team members, clinicians, expert consultants, and vendors

Education and Experience:

• Advanced scientific degree. PhD, MD, or PharmD preferred
• Experience in adeno-associated virus (AAV) gene therapy and/or rare neuromuscular indications required
• 5+ years of industry experience with 3+ years of clinical research experience across Phase 1 to Phase 3 studies
• Knowledge of clinical trial methodology, GCP, ICH, and regulatory and compliance requirements for the design and execution of clinical study protocols
• Experience in clinical data collection, review, and reporting, including the development of CRFs and the use of EDC/RTSM/IRT/other relevant systems
• Experience in preparation of INDs, BLAs/NDAs, and other regulatory documents
• Experience with medical writing and systematic literature review
• Experience cultivating and managing critical relationships at all levels inside and outside of the organization

Travel Commitment:

Up to approximately 20% travel required domestically and internationally

Position Location:

Hybrid (based out of Charlestown, MA headquarters office) or Remote if capable of normally working Eastern Time business hours