Scientist/Sr. Scientist, CMC Drug Substance Development

Join us in transforming the lives of patients
Are you passionate about making a significant impact in improving patients’ lives? At Enanta, we are committed to discovering and developing novel small molecule drugs for indications in virology and immunology. Our collaborative, fast-paced environment empowers every team member to meaningfully contribute to our goal of advancing healthcare and improving patient outcomes.

What You'll Do
As a Scientist/Sr. Scientist, CMC Drug Substance Development, you will be an integral part of our CMC team, leading and supporting the development of robust, safe, and cost-effective processes for small molecule drug substance manufacturing from early development through clinical and commercial readiness.

• Design and execute experiments: Plan, conduct, and interpret in-house laboratory studies to develop scalable synthetic routes and conduct scale up of starting materials, intermediates, and APIs.
• Drive drug substance development: Lead and support early- to late-stage manufacture process development, drug substance solid form study, establish control strategy to meet quality requirement
• Improve process robustness: Identify gaps, perform risk assessments, and recommend scientific strategies to ensure safe, cost-effective, phase-appropriate processes.
• Generate technical documentation: Prepare high-quality reports, presentations, and other technical content to support DS development, technology transfer to CDMO partners and regulatory filings
• Collaborate across functions: Partner with Analytical, Drug Product, Regulatory, QA, Project Management, Medicinal Chemistry, and external collaborators to advance program objectives.
• Support execution and scientific growth: Help coordinate internal and external CMC activities, manage timelines and materials, and share technical knowledge with colleagues as appropriate.

What You Bring

• Educational background: Advanced degree in Synthetic Organic Chemistry, Medicinal Chemistry, Physical Organic Chemistry, or a related scientific discipline, Ph.D. preferred.
• Professional experience: Scientist position requires Ph.D. degree with 0-2 years of post-graduation experience (postdoctoral or industrial), or M.S. degree with 3-5 years of industrial experience. Sr. Scientist level candidates should bring additional depth of experience and demonstrated impact in pharmaceutical or biotechnology settings.
• Technical expertise: Strong understanding of organic chemistry principles, laboratory operations, data analysis, and chemical process development.
• CMC and process knowledge: Hands-on experience in chemical process research and development, scale-up, and/or manufacturing for small molecule drug substances. Experience in large scale and kilo-lab operation is a plus.
• Regulatory and quality awareness: Familiarity with cGMP compliance, relevant ICH quality guidelines, and drug substance CMC documentation is a plus.
• Communication and execution: Excellent written and verbal communication skills with the ability to collaborate across teams, manage multiple priorities, and deliver high-quality work in a fast-paced environment.

What Sets You Apart

• I ndustry experience: Experience in the pharmaceutical or biotechnology industry supporting CMC development of small molecule programs.
• Development toolkit familiarity: Exposure to process development tools and equipment such as reactors, EasyMax, PAT, or related laboratory and scale-up technologies.
• Scientific judgment: Strong critical scientific thinking and the ability to identify issues, evaluate options, and influence decisions using data and logic.
• Broader CMC perspective: Understanding of CMC operations across lab, pilot, and manufacturing environments and the ability to work effectively across the development lifecycle.

Our Core Values
At Enanta, we foster a culture driven by the following core values:

• Curiosity: You demonstrate an unrelenting desire to explore, question, and innovate.
• Respectful: You engage with colleagues and partners with professionalism and care.
• Empathy: You are compassionate, both in teamwork and when thinking about patient impact.
• Agility: You thrive in fast-paced environments and adapt quickly to changing circumstances.
• Team-Oriented: You embrace collaboration, understanding that success comes from collective efforts.
• Entrepreneurial Spirit: You are proactive, continuously seeking opportunities to improve and grow.

Why Join Us?
At Enanta Pharmaceuticals, you will be part of a team working on projects and programs that truly matter. We offer a supportive, inclusive environment where innovation is not just encouraged but celebrated. You’ll have the opportunity to grow, collaborate, and make a tangible impact.

Enanta is committed to providing compensation transparency. The expected base salary range for this position is $96,000 to $149,333, based on experience, qualifications, and market conditions. Offers will be determined by several factors, including individual experience and expertise, ensuring both equity and competitiveness.

How to Apply

Please complete the application below and include the following attachments:

• Cover Letter
• CV / Resume
• Research Summary (if applicable)

About Enanta

Enanta is using its robust, chemistry-driven approach and drug discovery capabilities to become a leader in the discovery and development of small molecule drugs with an emphasis on indications in virology and immunology. Enanta’s clinical programs are currently focused on respiratory syncytial virus (RSV) and its earlier-stage immunology pipeline aims to develop treatments for inflammatory diseases by targeting key drivers of the type 2 immune response, including KIT, STAT6 and MRGPRX2 inhibition.

Glecaprevir, a protease inhibitor discovered by Enanta, is part of one of the leading treatment regimens for curing hepatitis C virus (HCV) infection and is sold by AbbVie in numerous countries under the tradenames MAVYRET® (U.S.) and MAVIRET® (ex-U.S.) (glecaprevir/pibrentasvir). A portion of Enanta’s royalties from HCV products developed under its collaboration with AbbVie contribute ongoing funding to Enanta’s operations. Please visit for more information.

 

E n anta Pharmaceuticals is an equal opportunity employer (EOE) with a commitment to diversity. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to race, color, national origin, age, religious creed, gender, gender identity, sexual orientation, physical or mental disability, protected veteran status, or any other class protected by law.